Cancer gene therapy targeting cellular apoptosis machinery
نویسندگان
چکیده
منابع مشابه
Targeting apoptosis pathways in cancer therapy.
Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to control cell proliferation or in response to DNA damage. The understanding of apoptosis has provided the basis for novel targeted therapies that can induce death in cancer cells or sensitize them to established cytotoxic agents and radiation therapy. These novel agents include those targeting the extrinsic pathw...
متن کاملApoptosis and Molecular Targeting Therapy in Cancer
Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they ar...
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Current treatment of solid tumors is limited by severe adverse effects, resulting in a narrow therapeutic index. Therefore, cancer gene therapy has emerged as a targeted approach that would significantly reduce undesired side effects in normal tissues. This approach requires a clear understanding of the molecular biology of both the malignant clone and the biological vectors that serve as vehic...
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Gene therapy is a promising approach towards cancer treatment. The main aim of the therapy is to destroy cancer cells, usually by apoptotic mechanisms, and preserving others. However, its application has been hindered by many factors including poor cellular uptake, non-specific cell targeting and undesirable interferences with other genes or gene products. A variety of strategies exist to impro...
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Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates fo...
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2012
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2012.06.008